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LRP4 Autoantibody Test
Test Code94744
CPT Codes
86255
Preferred Specimen
2 mL serum
Minimum Volume
0.5 mL
Instructions
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 25 days
Frozen: 25 days
Refrigerated: 25 days
Frozen: 25 days
Methodology
Immunofluorescence Assay (IFA)
Setup Schedule
Set up: As needed; Report available: 7-14 days
Clinical Significance
Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK.
