Interstitial Lung Disease Panel

Test Code

39149

CPT Codes
86235 (x10), 84182 (x6), 86200, 83516, 83520, 86431

Includes

Mutated Citrullinated Vimentin (MCV) Antibody
Rheumatoid Factor
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
RNP Antibody
RNA Polymerase III Antibody
Interstitial Lung Disease Panel, Line Blot (Ro-52 Ab, Th/To Ab, Fibrillarin (U3-snRNP) Ab, Centromere B Ab, Centromere A Ab, MDA5 Ab, OJ Ab, EJ Ab, PL-12 Ab, PL-7 Ab, Ku Ab, PM/Scl 75 Ab, PM/Scl 100 Ab, Jo-1 Ab, Scl-70 Ab)

Preferred Specimen

5.2 mL serum collected in a red-top tube (no gel)

Minimum Volume

2.6 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross and moderate hemolysis • Grossly lipemic • Grossly icteric • Serum separator tube (SST)

Methodology
Enzyme Linked Immunosorbent Assay (ELISA) • Immunoturbidimetry • Multiplex Flow Immunoassay • Line Blot

Setup Schedule

See individual assays; Report available: 3-9 days

Clinical Significance

A subset of interstitial lung disease (ILD) patients have underlying connective tissue diseases (CTDs). This panel serves as an aid for the diagnosis of CTDs, including rheumatoid arthritis, inflammatory myositis, systemic sclerosis, and Sjogren’s syndrome, that are associated with the development of ILD. If left untreated, these CTD patients may develop lung fibrosis and inflammation. ILD is a direct consequence of these pathological changes. When severe, ILD leads to restrictive lung disease, pulmonary arterial hypertension, and cardiac disease (cor pulmonale).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.