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Total Glutathione in Whole Blood
Test Code38813
CPT Codes
82978
Preferred Specimen
1 full tube whole blood collected in an ACD solution B (yellow-top) tube
Minimum Volume
1 full tube
Instructions
Do not centrifuge. Send whole tube.
Solution B specimen volume is 6 mL.
ACD collection tubes must be > 50% filled in order to ensure proper mixture of ACD solution.
Solution B specimen volume is 6 mL.
ACD collection tubes must be > 50% filled in order to ensure proper mixture of ACD solution.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Samples oversaturated with ACD solution
Methodology
Kinetic
FDA Status
The performance characteristics of the listed assay was validated by BioAgilytix Diagnostics. The US FDA has not approved or cleared this test. The results of this assay can be used for clinical diagnosis without FDA approval. BioAgilytix Diagnostics is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.
Setup Schedule
Set up: Daily; Report available: Up to 3 business days
Clinical Significance
Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as parkinson's disease. High levels of glutathione have been linked to chemotherapy resistance in cancer treatments.
