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FISH, MLL (11q23) Gene Rearrangement, Technical Component
Test Code37886
CPT Codes
88275, 88271 (x2)
Preferred Specimen
3 - 5 mL bone marrow or whole blood collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Sodium heparin (royal blue-top) • Sodium heparin lead-free (tan-top)
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: Unacceptable
Refrigerated: See Instructions
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Fluorescence In Situ Hybridization
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 5 to 7 days.
Clinical Significance
This test is performed to detect the rearrangements of MLL (KMT2A; 11q23) gene by FISH (fluorescence in situ hybridization). MLL rearrangements have been observed in hematologic neoplasms of either lymphoid or myeloid origin.
