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FISH, IGH/CCND1, Technical Component
Test Code37877
CPT Codes
88275 88271 (x2)
Preferred Specimen
3 - 5 mL whole blood or bone marrow collected in sodium heparin tube
5 x 5 mm fresh tissue in culture transport medium or sterile container with Hanks' or Ringers' solution
Formalin fixed paraffin embedded tissue block
5 x 5 mm fresh tissue in culture transport medium or sterile container with Hanks' or Ringers' solution
Formalin fixed paraffin embedded tissue block
Minimum Volume
1 mL
Instructions
Specimen viability decrease during transit. Send specimen to testing lab for viability.
Transport Temperature
Room temperature
Specimen Stability
Whole blood or Bone marrow or Fresh Tissue
Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: Unacceptable
Formalin fixed paraffin embedded tissue (see instruction)
Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: Unacceptable
Formalin fixed paraffin embedded tissue (see instruction)
Methodology
Fluorescence In Situ Hybridization (FISH)
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 5 to 7 days.
Clinical Significance
This test is performed to detect the IGH-CCND1 fusion, translocation t(11;14) by FISH (fluorescence in situ hybridization). This assay is useful for diagnosis of mantle cell lymphoma and, risk assessment for plasma cell myeloma.
