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FISH, CML/ALL, bcr/abl, Translocation 9,22, Technical Component
Test Code37875
CPT Codes
88275, 88271 (x2)
Preferred Specimen
3 - 5 mL whole blood or bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Sodium heparin (royal blue-top) • Sodium heparin lead-free (tan-top)
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: Unacceptable
Refrigerated: See Instructions
Frozen: Unacceptable
Methodology
Fluorescence In Situ Hybridization (FISH)
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 5 to 7 days.
Clinical Significance
This test is performed to detect the molecular rearrangement of the BCR and ABL1 genes involved in translocation t(9;22) associated with chronic myelogenous leukemia (CML), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) using FISH (fluorescence in situ hybridization). This test may be used in the evaluation of Ph negative CML, complex rearrangements or for followup to therapy for previously diagnosed Ph+ patients.
