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Clorazepate (Tranxene®)
Test Code90854
CPT Codes
80346 (HCPCS: G0480)
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube or ACD (yellow-top) tube
Instructions
Use polypropylene tubes
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 60 days
Refrigerated: 7 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST®)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Sets up 1 day a week.
Clinical Significance
Orally administered clorazepate is rapidly decarboxylated to its metabolite, nordiazepam. There is essentially no circulating patent drug. Nordiazepam elimination half-life is about 40 to 50 hours. Plasma levels of nordiazepam increase proportionally with clorazepate dose and show moderate accumulation with repeated administration.
