A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Industrial Cadmium Screen
Test Code8887
CPT Codes
82232, 82300 (x2), 82570
Includes
Beta-2-Microglobulin, Urine
Cadmium, Blood
Cadmium, Urine
Creatinine, Random Urine
Cadmium, Blood
Cadmium, Urine
Creatinine, Random Urine
Preferred Specimen
4 mL whole blood collected in an EDTA (royal blue-top) tube or sodium heparin (royal blue-top) tube and
7 mL random urine collected in an acid-washed or metal-free container and
10 mL random urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport tube (available through Client Supply)
7 mL random urine collected in an acid-washed or metal-free container and
10 mL random urine collected in a Quest Diagnostics Beta-2 Microglobulin Transport tube (available through Client Supply)
Minimum Volume
2 mL whole blood • 3 mL urine in an acid-washed or metal-free container • 10 mL urine in Beta-2 Microglobulin tube
Other Acceptable Specimens
See Collection Instructions
Instructions
Three separate collections are required. One collection of blood and two separate collections of urine.
Specimen 1: One EDTA (royal blue-top) tube or sodium heparin (royal blue-top) tube of whole blood.
Specimen 2: For urine cadmium and creatinine: Collect urine in an acid-washed or metal-free plastic container. Label as Cadmium/Creatinine.
Specimen 3: Once patient has voided bladder for cadmium/creatinine collection,
1. Patient should void bladder, then drink at least 500 mL (approximately 17 oz) of water.
2. A urine sample should be collected within 1 hour.
3. Pour exactly 10 mL of random urine into a Quest Diagnostics Beta-2 Microglobulin Transport Tube (#179979 available through Client Supply).
4. Ship refrigerated.
5. Alternatively, if the collection tubes are not available, pH the specimen to between 6 and 8 using 1N NaOH prior to shipping.
Beta-2 Microglobulin in urine is unstable in acidic urine (less than pH 6). Exactly 10 mL of urine in the Quest Diagnostics Beta-2 Microglobulin Transport Tube is required to achieve the required pH of between 6 and 8. Any volume above or below 10 mL will result in a pH that is outside the acceptable range.
Specimen 1: One EDTA (royal blue-top) tube or sodium heparin (royal blue-top) tube of whole blood.
Specimen 2: For urine cadmium and creatinine: Collect urine in an acid-washed or metal-free plastic container. Label as Cadmium/Creatinine.
Specimen 3: Once patient has voided bladder for cadmium/creatinine collection,
1. Patient should void bladder, then drink at least 500 mL (approximately 17 oz) of water.
2. A urine sample should be collected within 1 hour.
3. Pour exactly 10 mL of random urine into a Quest Diagnostics Beta-2 Microglobulin Transport Tube (#179979 available through Client Supply).
4. Ship refrigerated.
5. Alternatively, if the collection tubes are not available, pH the specimen to between 6 and 8 using 1N NaOH prior to shipping.
Beta-2 Microglobulin in urine is unstable in acidic urine (less than pH 6). Exactly 10 mL of urine in the Quest Diagnostics Beta-2 Microglobulin Transport Tube is required to achieve the required pH of between 6 and 8. Any volume above or below 10 mL will result in a pH that is outside the acceptable range.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Whole blood
Room temperature: 48 hours
Refrigerated: 5 days
Frozen: Unacceptable
Cadmiun & Creatinine Urine
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 14 days
Beta-2 Microglobulin Urine
Room temperature: 5 days
Refrigerated: 15 days
Frozen: 30 days
Room temperature: 48 hours
Refrigerated: 5 days
Frozen: Unacceptable
Cadmiun & Creatinine Urine
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 14 days
Beta-2 Microglobulin Urine
Room temperature: 5 days
Refrigerated: 15 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Beta-2 Microglobulin: Specimens received in a non-Beta-2 Microglobulin transport tube with a pH <6 • Any volume other than 10 mL urine in the transport tube • Any specimen with pH <6
Methodology
Colorimetric (C) • Inductively Coupled Plasma/Mass Spectrometry (ICP/MS) • Kinetic • Nephelometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Wed, Fri: Report Available: 1 day
Clinical Significance
This panel is used for monitoring workers for potential exposure to cadmium in the workplace. The beta-2-microglobulin, blood and urine cadmium are integrated to specify the exposure category.