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Selenium, Blood
Test Code6296
CPT Codes
84255
Preferred Specimen
2 mL whole blood collected in an EDTA trace metal-free (royal blue-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Royal blue-top (Sod Hep) trace element free w/green band • Sodium heparin (green-top) • EDTA (lavender-top)
Instructions
Carefully clean skin prior to venipuncture. Avoid worksite collection. Use the royal blue-top trace metal evacuated tube, which is available with EDTA or heparin.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 30 days
Frozen: 60 days
Refrigerated: 30 days
Frozen: 60 days
Methodology
Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Sets up 2 days a week.
Clinical Significance
Selenium (Se) is a key component of a number of functional selenoproteins required for normal health. The best known of these are the antioxidant glutathione peroxidase enzymes, which remove hydrogen and damaging lipid and phospholipid hydroperoxides generated in vivo by free radicals and other oxygen-derived species. If not removed, lipid hydroperoxides impair membrane structure and function and cause blood-clotting disturbances by decreasing the production of prostacyclin while increasing the production of thromboxane.