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Flunitrazepam and Metabolites, Quantitative, Serum
Test Code18964
CPT Codes
80346 (HCPCS: G0480)
Includes
Flunitrazepam, 7-Aminoflunitrazepam, and N-Desmethylflunitrazepam
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Instructions
Do not use serum separator tubes
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 60 days
Refrigerated: 14 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST®)
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Sets up 1 day a week.
Clinical Significance
In Latin America and Europe, Rohypnol (Flunitrazepam) is prescribed as a short-term treatment for insomnia, and as a preanesthetic medication. Flunitrazepam is considered a drug of abuse when used to enhance the effect of other substances such as marijuana, heroin, and ethanol. The combination of ethanol and flunitrazepam may lead to sedation, loss of motor function, impaired judgement, behavioral changes, and anterograde amnesia.