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Clozapine
Test Code1769
CPT Codes
80159
Includes
Clozapine and Norclozapine
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum separator tube (SST)
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Set up: Tues-Sat; Report available: 1-3 days
Clinical Significance
Clozapine is an atypical antipsychotic agent. Norclozapine has minimal therapeutic activity.
