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TRAb (TSH Receptor Antibody)
Test Code38683
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Allow serum to clot at room temperature. Serum must be separated from the cells or gel barrier within 1 hour of collection and poured into a transport vial.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Serum received in a gel barrier tube or on the cells
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
Night Sets up 3 days a week.
Clinical Significance
Measurement of TRAb is used to diagnose and manage Graves' disease, neonatal hypothyroidism, and postpartum thyroid dysfunction. TRAb, which measures the ability of antibodies to inhibit TSH binding to its receptor, reflects the presence of either or both the stimulatory and inhibitory immunoglobulin classes.
