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CAH Panel 6 (StAR Deficiency)
Test Code15276
CPT Codes
82533, 84140, 82626, 82088
Includes
Cortisol, Total, LC/MS
Pregnenolone, LC/MS
DHEA (Dehydroepiandrosterone) Unconjugated
Aldosterone, LC/MS
Pregnenolone, LC/MS
DHEA (Dehydroepiandrosterone) Unconjugated
Aldosterone, LC/MS
Preferred Specimen
4 mL serum collected in a red-top tube (no gel)
Minimum Volume
1.6 mL
Instructions
Collect blood in a Vacutainer® with no additives. Allow blood to clot (30 minutes) at room temperature, 18-25°C. Centrifuge and separate the serum from the cells. Freeze as soon as possible.
Specify age and sex on test request form. Immediately put sample on ice after collection.
Specify age and sex on test request form. Immediately put sample on ice after collection.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days
Refrigerated: 72 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate to gross hemolysis • Serum Separator Tube (SST®) • Plasma
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Clinical Significance
Steroidogenic acute regulatory protein (StAR) catalyzes the initial rate-limiting in the formation of steroid hormones. Affected individuals present with deficiency of cortisol and aldosterone, as well as early precursors in the synthesis of steroid hormones (Pregnenalone; DHEA (Dehydroepiandrosterone). Additional testing may be required to establish a diagnosis.