Angiotensin II Type 1 Receptor (AGTR1) Gene 1166A→C Polymorphism

Test Code

11118

CPT Codes
81400

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

3 mL

Other Acceptable Specimens

Whole blood collected in: ACD solution B (yellow-top) or sodium heparin (green-top) tube

Instructions

Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Call laboratory if blood samples received frozen

Methodology
Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Wed, Sat; Report available 6-10 days

Clinical Significance

The ATR1 receptor gene polymorphism is associated with increased risk for hypertension and cardiovascular risk. Substantial increase in the c allele frequency was observed among patients with severe hypertension, particularly among individuals carrying DD ACE genotype.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.