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HPV Genotypes 16 and 18, Cervical
Test Code19865
CPT Codes
87625
Preferred Specimen
3 mL (PreservCyt®) fluid collected in ThinPrep® vial or
2 mL SurePath™ fluid collected in SurePath™ vial
2 mL SurePath™ fluid collected in SurePath™ vial
Minimum Volume
ThinPrep®: 1.5 mL • SurePath™: 1 mL
Other Acceptable Specimens
2 mL residual SurePath™ fluid collected in SurePath™ vials
Instructions
Collect the sample as usual according to the manufacturer's instructions.
Transport Temperature
Room temperature
Specimen Stability
ThinPrep®
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
SurePath™
Room Temperature: 28 days
Refrigerated: 90 days
Frozen: Unacceptable
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
SurePath™
Room Temperature: 28 days
Refrigerated: 90 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen • Cervical swabs in Digene® HC cervical sampler • Unprocessed Cytyc® media without cervical brush/broom • Swabs • Digene® vials • SurePath™ pellet • Samples treated with acetic acid • Vaginal sources • Biopsy
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Set up: Tues, Thurs, Sat; Report available: 1-3 days
Clinical Significance
Persistent infection with high-risk HPV types increases a woman's risk for progression to dysplasia or cervical cancer. The rate of progression or degree of risk depends on the HPV type. Of all various high-risk types, HPV Types 16 and 18 cause more than 60-65% of cervical cancers. This test will identify the presence or absence of HPV Type 16 DNA and/or Type 18 DNA. Knowledge of the HPV genotype will help physicians diagnose the type of HPV infection and its risk of developing into dysplasia or cervical cancer.
