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FISH, AML, CBFB/MYH11, Inversion 16
Test Code10635
CPT Codes
88271 (x2), 88275
Preferred Specimen
5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube
Instructions
Bone marrow 1-3 mL, or whole blood 3-5 mL, sodium heparin only
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 5 to 7 days.
Clinical Significance
This test is performed to detect the CBFB rearrangements such as inversion (16) and translocation t(16;16), by FISH (fluorescence in situ hybridization). This assay is useful for diagnosis of acute myeloid leukemia (AML) with inv(16) or t(16;16); CBFB-MYH11.