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Pre-biologic/biosimilar Screen Panel, HCV/HBV with Reflexes and QFT 1 Tube
Test Code37616
CPT Codes
86480, 87340, 86317, 86704, 86803
Includes
QuantiFERON®-TB Gold Plus, 1 Tube
Hepatitis B Surface Antigen with Reflex Confirmation
Hepatitis B Surface Antibody Immunity, Quantitative
Hepatitis B Core Antibody, Total, with Reflex to IgM
Hepatitis C Antibody with Reflex to HCV RNA,PCR w/Reflex to Genotype, LiPA
Hepatitis B Surface Antigen: Reactive samples will be confirmed based on the manufacturer's FDA approved recommendations at an additional charge (CPT code(s): 87341).
If Hepatitis B Core Antibody Total is reactive, then Hepatitis B Core IgM Antibody will be performed at an additional charge (CPT code(s): 86705).
If Hepatitis C Antibody is reactive, then Hepatitis C Viral RNA, Quantitative, Real-Time PCR will be performed at an additional charge (CPT code(s): 87522).
If Hepatitis C Viral RNA, Quantitative, Real-Time PCR is ≥300 IU/mL, then Hepatitis C Viral RNA Genotype, LiPA will be performed at an additional charge (CPT code(s): 87902).
Hepatitis B Surface Antigen with Reflex Confirmation
Hepatitis B Surface Antibody Immunity, Quantitative
Hepatitis B Core Antibody, Total, with Reflex to IgM
Hepatitis C Antibody with Reflex to HCV RNA,PCR w/Reflex to Genotype, LiPA
Hepatitis B Surface Antigen: Reactive samples will be confirmed based on the manufacturer's FDA approved recommendations at an additional charge (CPT code(s): 87341).
If Hepatitis B Core Antibody Total is reactive, then Hepatitis B Core IgM Antibody will be performed at an additional charge (CPT code(s): 86705).
If Hepatitis C Antibody is reactive, then Hepatitis C Viral RNA, Quantitative, Real-Time PCR will be performed at an additional charge (CPT code(s): 87522).
If Hepatitis C Viral RNA, Quantitative, Real-Time PCR is ≥300 IU/mL, then Hepatitis C Viral RNA Genotype, LiPA will be performed at an additional charge (CPT code(s): 87902).
Preferred Specimen
6 mL whole blood collected in a lithium heparin (green-top) tube AND 2.5 mL serum collected in each of two separate serum separator tubes AND 2.5 mL serum
Minimum Volume
Serum: 2.5 mL
Serum: 2.5 mL (X2) [x2]
Whole blood: 5 mL
Serum: 2.5 mL (X2) [x2]
Whole blood: 5 mL
Instructions
Collect a minimum of 6 mL of blood by venipuncture into a lithium heparin (green-top) tube. Gently mix by inverting the tube several times to dissolve the heparin. Refrigerate at 2-8°C.
The Centers for Disease Control and Prevention (CDC) has provided guidance on clinical considerations for tuberculosis (TB) testing such as QuantiFERON®-TB Gold Plus in conjunction with COVID-19 mRNA vaccines. Please refer to the QuantiFERON®-TB Gold Plus FAQ link (https://education.questdiagnostics.com/faq/FAQ204) for more detailed information on the latest CDC guidelines regarding TB testing and COVID-19 vaccines.
The Centers for Disease Control and Prevention (CDC) has provided guidance on clinical considerations for tuberculosis (TB) testing such as QuantiFERON®-TB Gold Plus in conjunction with COVID-19 mRNA vaccines. Please refer to the QuantiFERON®-TB Gold Plus FAQ link (https://education.questdiagnostics.com/faq/FAQ204) for more detailed information on the latest CDC guidelines regarding TB testing and COVID-19 vaccines.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
See Individual assays
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
See individual assays
Methodology
See Individual Assays
Setup Schedule
See Individual Assays
Clinical Significance
For patients diagnosed with any of a number of chronic autoimmune disorders (such as rheumatoid arthritis, plaque psoriasis, IBD and others), this panel combines screening for HCV, HBV and latent TB, all of which are required before initiating therapy with biologics and/or biosimilars. It is important to identify whether latent infections are present as they can rapidly manifest themselves in an immunosuppressed patient.
