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Chromosome Analysis and Alpha-Fetoprotein with Reflex to AchE and Fetal Hgb, Amniotic Fluid (NY)
Test Code17851
CPT Codes
88235, 88269, 88280, 82106<br><strong>This test code is for New York patient testing. For non-New York patient testing, use test code 14591.</strong>
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Includes
Chromosome Analysis, Banded and Alpha-Fetoprotein (AFP) with Reflexes
If the AFP MoM is >1.99, Acetylcholinesterase and Fetal Hemoglobin will be performed at an additional charge (CPT code(s): 82664, 83033).
If the AFP MoM is >1.99, Acetylcholinesterase and Fetal Hemoglobin will be performed at an additional charge (CPT code(s): 82664, 83033).
Preferred Specimen
20 mL amniotic fluid collected in a sterile screw-cap container
Minimum Volume
5 mL
Instructions
30 mL is preferred if other testing, e.g. microarray, FISH is ordered.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Culture • Microscopy • Karyotype • Gel Electrophoresis • Radial Immunodiffusion • AFP: Chemiluminescent
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 5 days a week.
Report Available
Reports in 10 days.
Clinical Significance
Prenatal detection of cytogenetic abnormalities, both numerical and structural, that may be associated with phenotypic and/or developmental abnormalities in the fetus. This test is also used to diagnose neural tube and ventral wall defects.
See Cytogenetics in the Genetics section of Test Application and Interpretation.
See Cytogenetics in the Genetics section of Test Application and Interpretation.