Chromosome Analysis and Alpha-Fetoprotein with Reflex to AchE and Fetal Hgb, Amniotic Fluid (NY)

Test Code

17851

CPT Codes
88235, 88269, 88280, 82106<br><strong>This test code is for New York patient testing. For non-New York patient testing, use test code 14591.</strong>

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Includes

Chromosome Analysis, Banded and Alpha-Fetoprotein (AFP) with Reflexes

If the AFP MoM is >1.99, Acetylcholinesterase and Fetal Hemoglobin will be performed at an additional charge (CPT code(s): 82664, 83033).

Preferred Specimen

20 mL amniotic fluid collected in a sterile screw-cap container

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g. microarray, FISH is ordered.

Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Culture • Microscopy • Karyotype • Gel Electrophoresis • Radial Immunodiffusion • AFP: Chemiluminescent

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Fri; Report available: 9-12 days additional days for reflex if needed

Clinical Significance

Prenatal detection of cytogenetic abnormalities, both numerical and structural, that may be associated with phenotypic and/or developmental abnormalities in the fetus. This test is also used to diagnose neural tube and ventral wall defects.

See Cytogenetics in the Genetics section of Test Application and Interpretation.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.