Zinc Protoporphyrin (ZPP)

Test Code

CPT Codes

Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube - protect from light

Minimum Volume
0.5 mL

Other Acceptable Specimens
Light protected whole blood collected in: EDTA (royal blue-top) tube • Sodium heparin (green-top) tube • Sodium heparin lead-free (tan-top) tube • EDTA K2 (tan-top) tube

Use lead-free tube if blood lead is also requested. Specimen should be foil wrapped. Protect from light.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 10 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received frozen • Clotted


FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available 1 days

Aluminum and anemia of chronic disease may cause elevated results.

Clinical Significance
Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.