F2-Isoprostane/Creatinine Ratio

Test Code

92771

CPT Codes
82542, 82570

Preferred Specimen

2 mL random urine collected in a preservative-free urine collection container (cup)

Minimum Volume

1.5 mL

Instructions

1. Collect urine sample in a preservative-free urine collection container (cup) according to standard protocols.
2. Transfer aliquot into a preservative-free urine specimen tube using the vacutainer transfer device included with the tube.
3. Label urine specimen tube according to standard protocols. Store and transport refrigerated. Discard urine collection container (cup).

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Specimens other than preservative-free urine

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics
Cardiometabolic Center of Excellence at Cleveland HeartLab. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 5 days

Clinical Significance

The F2-isoprostane/creatinine ratio is the "gold standard" for measuring oxidative stress and has utility in individuals who have lifestyle risks due to poor diet or smoking, a family history of cardiovascular disease, or hyperlipidemia. High levels are seen in conditions associated with increased risk of atherosclerosis and certain cancers.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.