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F2-Isoprostane/Creatinine Ratio
Test Code92771
CPT Codes
82542, 82570
Preferred Specimen
2 mL random urine collected in a preservative-free urine collection container (cup)
Minimum Volume
1.5 mL
Instructions
1. Collect urine sample in a preservative-free urine collection container (cup) according to standard protocols.
2. Transfer aliquot into a preservative-free urine specimen tube using the vacutainer transfer device included with the tube.
3. Label urine specimen tube according to standard protocols. Store and transport refrigerated. Discard urine collection container (cup).
2. Transfer aliquot into a preservative-free urine specimen tube using the vacutainer transfer device included with the tube.
3. Label urine specimen tube according to standard protocols. Store and transport refrigerated. Discard urine collection container (cup).
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens other than preservative-free urine
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Sets up 6 days a week.
Clinical Significance
The F2-isoprostane/creatinine ratio is the "gold standard" for measuring oxidative stress and has utility in individuals who have lifestyle risks due to poor diet or smoking, a family history of cardiovascular disease, or hyperlipidemia. High levels are seen in conditions associated with increased risk of atherosclerosis and certain cancers.
