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Acetylcholine Receptor Binding Antibody with Reflex to MuSK Antibody
Test Code94222
CPT Codes
86041
Includes
If Acetylcholine Receptor Binding Antibody is Negative, then MuSK Antibody Test will be performed at an additional charge (CPT cod(s): 86366)
Preferred Specimen
2 mL serum
Minimum Volume
0.5 mL
Instructions
Allow blood to clot at room temperature. Serum should be separated from cells within one hour.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Microbially contaminated
Methodology
Radioimmunoassay (RIA)
Setup Schedule
P.M. Sets up 7 days a week.
Report Available
Reports in 8 to 15 days.
Clinical Significance
Anti-acetylcholine receptor binding antibodies (anti-AChR) are associated with Myasthenia Gravis (MG) and are found in approximately 85% of MG patients. Approximately 8% to 10% of all MG cases and 20% to 50% of generalized MG cases who lack anti-AChR antibodies have autoantibodies against muscle-specific kinase (anti-MuSK).
