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Motilin
Test Code4791X
CPT Codes
83519<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
3 mL frozen serum collected in a red-top tube (no gel)
Patient Preparation
Fasting for 10 to 12 hours is required. Patient should refrain from taking anti-acid medication or medications affecting motility, if possible, 48 hours prior to specimen collection.
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Instructions
Separate from cells as soon as possible after clotting. Freeze immediately after separating from cells. Ship specimen frozen on dry ice.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 12 hours
Refrigerated: 7 days
Frozen: 1 year
Refrigerated: 7 days
Frozen: 1 year
Methodology
Direct Radioimmunoassay
FDA Status
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Setup Schedule
Set up: Mon-Fri; Report available: Once per month: <28 days
Clinical Significance
Motilin is a 22 amino acid peptide produced primarily by the enterochromaffin cells (EC2 or M cells) in the intestine, duodenum and jejunum. It is absent from the stomach and colon. Motilin accelerates gastric emptying and colonic motor activity. Motilin also stimulates the feeding response. It has no structural similarities with other gastrointestinal peptides. Motilin secretion can be stimulated by acid and a fat-rich meal. Motilin can increase the secretion of Pepsin and causes increased intra-gastric pressure. Motilin also stimulates lower esophageal sphincter contraction. Motilin levels are suppressed by Calcitonin. Motilin has a short half-life of approximately five minutes.
