Motilin

Test Code

4791

CPT Codes
83519<br><strong>This test is not available for New York patient testing.</strong>

Preferred Specimen

3 mL frozen serum collected in a red-top tube (no gel)

Patient Preparation
Patient should be fasting 10 - 12 hours prior to collection of specimen. Patient should not be on any antacid medication or medications affecting intestinal motility, if possible, for at least 48 hours prior to collection.

Minimum Volume

1 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube

Instructions

Serum or plasma should be collected and separated as soon as possible. Freeze specimens immediately after separation.

Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology
Direct Radioimmunoassay

FDA Status
This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

Setup Schedule

Setup: Varies; Report available: 14 business days

Clinical Significance

Motilin is a 22 amino acid peptide produced primarily by the enterochromaffin cells (EC2 or M cells) in the intestine, duodenum and jejunum. It is absent from the stomach and colon. Motilin accelerates gastric emptying and colonic motor activity. Motilin also stimulates the feeding response. It has no structural similarities with other gastrointestinal peptides. Motilin secretion can be stimulated by acid and a fat-rich meal. Motilin can increase the secretion of Pepsin and causes increased intra-gastric pressure. Motilin also stimulates lower esophageal sphincter contraction. Motilin levels are suppressed by Calcitonin. Motilin has a short half-life of approximately five minutes.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.