Heparin-Induced Platelet Antibody with Reflex to SRA, Unfractionated Heparin

Test Code

15334

CPT Codes
86022<br><strong>This test is not approved for New York patient testing.</strong>

Includes

If Heparin-Induced Platelet Antibody is a weak positive or positive, then Serotonin Release Assay (SRA), Unfractionated Heparin will be performed at an additional charge (CPT code(s): 86022)

Preferred Specimen

1 mL serum collected in each of two separate red-top tubes (no gel)

Minimum Volume

0.5 mL (x2)

Instructions

Centrifuge red-top tube 15 minutes at approximately 1500 g as soon as possible after clotting

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Lipemic • Icteric • Serum separator tube (SST)

Methodology
Immunoassay (IA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

See individual assays

Clinical Significance

Diagnosis of Heparin Induced Thrombocytopenia is based on clinical criteria but serological confirmation is often necessary. The ELISA assay measures the Platelet Factor 4/Heparin Complex to IgG. When the ELISA test is positive, testing by Serotonin Release Assay (a platelet activation assay) is more predictive of thrombocytopenia and thrombosis.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.