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Porphyrins, Fractionated, Plasma
Test Code5519
CPT Codes
82542
Includes
Uroporphyrin, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Coproporphyrin, Protoporphyrin, Total Porphyrins
Preferred Specimen
2 mL frozen plasma collected in a sodium heparin (green-top) tube - protect from light
Minimum Volume
0.6 mL
Other Acceptable Specimens
Frozen plasma collected in: EDTA (lavender-top) tube - protect from light • Serum collected in: Red-top tube (no gel) - protect from light
Instructions
Collect blood sample with light-protected green-top tube.
Separate plasma by centrifugation. Avoid hemolysis.
Remove plasma to a light-protected tube.
Freeze immediately after separation.
Separate plasma by centrifugation. Avoid hemolysis.
Remove plasma to a light-protected tube.
Freeze immediately after separation.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 8 hours
Refrigerated: 8 hours
Frozen: 90 days
Refrigerated: 8 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST®)
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun, Wed; Report available: 5-10 days
Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyrias and excluding porphyrias in patients with chronic renal failure suspected of having a porphyria.
