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17-Hydroxy Progesterone, Random Urine
Test Code39488
CPT Codes
83498<br /> ** This test is not approved for New York patient testing **
Preferred Specimen
10 mL random urine, no preservative in a plastic leak-proof container
Patient Preparation
Patient should not be on any corticosteroid, ACTH, estrogen, or gonadotropin medications, if possible, for at least 48 hours prior to collection of specimen
Minimum Volume
5 mL
Other Acceptable Specimens
Random urine submitted in a plastic, leakproof container
Instructions
10 ml of a random urine collection should be submitted for analysis. No special preservatives are required. Store specimen refrigerated during collection. Specimens should be frozen prior to shipping. Minimum specimen size is 5 ml.
Note: Ship specimens frozen on dry ice. Provide the total volume.
Note: Ship specimens frozen on dry ice. Provide the total volume.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 1 hour
Refrigerated: 4 days
Frozen: 30 days
Refrigerated: 4 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly icteric • Gross hemolysis • Grossly lipemic
Methodology
Radioimmunoassay (RIA) following Extraction
FDA Status
This test was performed using a kit that has been approved by the FDA for an alternate matrix. The analytic performance characteristics of this test for the submitted matrix have been determined by Inter Science Institute.
Setup Schedule
Set up: Varies; Report available: 7 business days
Clinical Significance
17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with polycystic ovarian disease and congenital adrenal hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21 alpha-hydroxylase deficient congenital adrenal hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.
