Prostaglandin E2, Serum/Plasma

Test Code

91901

CPT Codes
84150

Preferred Specimen

3 mL frozen serum collected in a red-top tube (no gel) or 3 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume

1 mL

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unstable
Refrigerated: 24 hours
Frozen: 90 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Received room temperature • Received refrigerated • Serum Separator Tube (SST®)

Methodology
Enzyme Linked Immunosorbent Assay (ELISA) • Extraction

FDA Status
The performance characteristics of this test were determined by Pan Laboratories, Irvine, CA. It has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

A.M. Sets up 1 day a week.

Clinical Significance

Prostaglandins are synthesized from arachidonic acid by cyclooxygenase (COX)-1 or -2, which converts the acid into PGH2. This is further processed by cytosolic or microsomal prostaglandin synthesis to become prostaglandin E2. PG E2 is produced in many tissues and the level is increased during inflammation, arthritis, fever, endometriosis, tissue injury, pheochromocytoma, VIP producing tumors and variety of cancers with amine peptide productions. Prostaglandin E2 production and circulating levels are reduced by aspiring and indomethacin treatment.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.