Pepsinogen II

Test Code

11261

CPT Codes
83519<br /> <strong>This test is not available for New York patient testing.</strong>

Preferred Specimen

3 mL serum collected in a red-top (no gel)

Patient Preparation
Patient should be fasting 10-12 hours prior to collection of specimen. Antacids or other medications affecting stomach acidity of gastrointestinal motility should be discontinued, if possible, for at least 48 hours prior to collection.

Minimum Volume

1 mL

Other Acceptable Specimens

EDTA (lavender-top)

Instructions

Separate and freeze immediately in plastic vial. Ship specimen frozen on dry ice.

Transport Temperature

Frozen

Specimen Stability

Room temperated: Unacceptable
Refrigerated: 72 hours
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology
Radioimmunoassay (RIA)

FDA Status
This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

Setup Schedule

Set up: Varies; Report available: 7 business days

Clinical Significance

The Pepsinogens are gastric acid protease zymogens. They are divided into two distinct immunochemical groups. Pepsinogen I and II. Pepsinogen II is one of 4 aspartic proteinases: PG I, PG II, Cathepsin E and D. Pepsinogen II is produced primarily in the Oxyntic gland mucosa of the stomach, the gastric antrum and the duodenum. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen II has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Unlike Pepsinogen I, Pepsinogen II is not normally found in the urine. Patients with pernicious anemia have low to non-detectable levels of Pepsinogen I but normal levels of Pepsinogen II. Pepsinogen II levels are slightly elevated in gastric ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.