FISH, Product of Conception (POC) Panel

Test Code

14820

CPT Codes
88271 (x7), 88274 (x3)<br /> **This test is not approved New York for patient testing.**

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

5 x 5 mm tissue collected in a sterile container in Hank's Ringer's Solution or Culture medium with antibiotics

Minimum Volume

2 x 3 mm

Other Acceptable Specimens

2 x 3 mm tissue in a formalin-fixed, paraffin-embedded block

Instructions

See Genetics Specimen Collection Section for detailed specimen instructions.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. **Do not reject**

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M.

Limitations

The FISH test is limited in that it only counts the number of each of the included chromosomes (13, 16, 18, 21, 22, X, and Y). This assay will not detect chromosome mosaicism, duplications, deletions, or structural rearrangements and does not identify all birth and/or developmental abnormalities.

Clinical Significance

Approximately 15% of all clinically recognized pregnancies are spontaneously aborted (SAB). A significant number of these samples in culture do not yield metaphase cells to perform cytogenetic studies. Using FISH probes will allow for detecting common cytogenetic abnormalities.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.