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Matrix Metalloproteinase-9 (MMP-9)
Test Code91237
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Frozen
Specimen Stability
Room temperature: 4 hours
Refrigerated: 24 hours
Frozen: 30 days
Refrigerated: 24 hours
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Received room temperature
Methodology
Immunoassay (IA)
FDA Status
The performance characteristics of this test were determined by Pan Laboratories, Irvine, CA. It has not been cleared or approved by the U.S. Food and Drug Administration.
Setup Schedule
Sets up 1 day a week.
Clinical Significance
Matrix metalloproteinases (MMPs) are a family of Zinc-dependent endopeptidases that degrade extracellular matrix proteins. Human MMP-9 Matrix metalloproteinase-9 (Gelatinase-B), with a molecular weight of 82 Kd, is inhibited by TIMP-1 and alpha 2 macroglobulin. MMP-9 is secreted by tumor cells, endothelial cells, fibroblasts and leucocytes.MMP-9 is involved in inflammation, tissue modeling, wound healing and processing of cytokines. Expression of MMP-9 correlates with abnormal collagen deposition that accompanies pancreatic cancer, with the metastasis to lymph nodes by human breast cancer cells and invasion of regional vessels in giant cell tumors of bones. MMP-9 is elevated in saliva in patients with gingivitis and periodontal diseases.