Purkinje Cell Cytoplasmic Antibody Type Tr (DNER), CBA IFA

Test Code

93894

CPT Codes
86255

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel) or CSF collected in a sterile screw-cap container

Minimum Volume

0.3 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST)

Methodology
Cell Binding Assay-Immunofluorescence Assay (CBA-IFA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes

Setup Schedule

Set up: Wed, Fri; Report available: 7-14 days

Clinical Significance

Delta/notch-like epidermal growth factor-related receptor (DNER) is a central nervous system-specific ligand for the Notch receptors expressed by cerebellar Purkinje neurons, essential for the normal development of Purkinje cells and Bergmann glia. DNER is the target of PCA-Tr antibodies associated with paraneoplastic cerebellar degeneration (PCD) in patients with Hodgkin's lymphoma.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.