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Paraneoplastic Antibody Evaluation with Reflex to Titer and LB, Basic, CSF
Test Code94536
CPT Codes
86255 (x10), 86341
Includes
Initial panel consits of: Paraneoplastic Antibody Screen, IFA
If the Paraneoplastic Ab Screen, IFA is positive for Aquaporin-4 Ab, IFA, then Aquaporin-4 (AQP4) Antibody (IgG), CBA, CSF will be performed at an additional charge (CPT code(s) 86052).
If Aquaporin-4 (AQP4) Antibody (IgG), CBA result is positive, then a titer will be performed at an additional charge (CPT code(s) 86052) .
If the Paraneoplastic Ab Screen, IFA is positive for ANNA3 Ab IFA, then a titer will be performed at an additional charge (CPT code(s) 86256) .
If the Paraneoplastic Ab Screen, IFA is positive for PCA2 Ab IFA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If the Paraneoplastic Ab Screen, IFA is indeterminate or positive for ANNA1, ANNA2, PCA1, PCA-Tr (DNER), Amphiphysin, GAD65, or CRMP5 (CV2) antibodies, then Paraneoplastic Antibody, Line Blot will be performed.
If the Paraneoplastic Ab Screen, IFA is positive for NMDAR1, LGI-1, CASPR2, AMPAR1, AMPAR2, GABA receptor B, or Voltage Gated Antibodies, then Paraneoplastic Antibody, CBA IFA will be performed.
If Paraneoplastic Antibody, CBA IFA is positive for NMDAR1 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for AMPAR1 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA, IFA is positive for AMPAR2 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for GABA receptor B Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for LGI-1 Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for CASPR2 Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If the Paraneoplastic Ab Screen, IFA is positive for LGI-1, CASPR2, or Voltage Gated Antibodies, then Voltage-Gated Potassium Channel (VGKC) Antibody, CSF will be performed at an additional charge (CPT code(s) 83519).
If the Paraneoplastic Ab Screen, IFA is positive for Aquaporin-4 Ab, IFA, then Aquaporin-4 (AQP4) Antibody (IgG), CBA, CSF will be performed at an additional charge (CPT code(s) 86052).
If Aquaporin-4 (AQP4) Antibody (IgG), CBA result is positive, then a titer will be performed at an additional charge (CPT code(s) 86052) .
If the Paraneoplastic Ab Screen, IFA is positive for ANNA3 Ab IFA, then a titer will be performed at an additional charge (CPT code(s) 86256) .
If the Paraneoplastic Ab Screen, IFA is positive for PCA2 Ab IFA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If the Paraneoplastic Ab Screen, IFA is indeterminate or positive for ANNA1, ANNA2, PCA1, PCA-Tr (DNER), Amphiphysin, GAD65, or CRMP5 (CV2) antibodies, then Paraneoplastic Antibody, Line Blot will be performed.
If the Paraneoplastic Ab Screen, IFA is positive for NMDAR1, LGI-1, CASPR2, AMPAR1, AMPAR2, GABA receptor B, or Voltage Gated Antibodies, then Paraneoplastic Antibody, CBA IFA will be performed.
If Paraneoplastic Antibody, CBA IFA is positive for NMDAR1 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for AMPAR1 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA, IFA is positive for AMPAR2 Ab CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for GABA receptor B Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for LGI-1 Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody, CBA IFA is positive for CASPR2 Ab, CBA, then a titer will be performed at an additional charge (CPT code(s) 86256).
If the Paraneoplastic Ab Screen, IFA is positive for LGI-1, CASPR2, or Voltage Gated Antibodies, then Voltage-Gated Potassium Channel (VGKC) Antibody, CSF will be performed at an additional charge (CPT code(s) 83519).
Preferred Specimen
3 mL CSF collected in a sterile leak-proof container
Minimum Volume
1.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Methodology
See individual assays
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Setup Varies; Report available: 3-12 days
Clinical Significance
Fluorescent staining patterns on multiple neuronal and non-neuronal tissues identify likely autoantibodies present. Reflex testing to western line blot, cell based indirect immunofluorescent assay or radioimmunoassay may define specific autoantibodies.
