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Chronic Urticaria Panel 3
Test Code90139
CPT Codes
83520, 86343
Includes
IgE Antibody (Anti-IgE IgG), Histamine Release (Chronic Urticaria)
Preferred Specimen
2.6 mL serum collected in a red-top (no gel)
Patient Preparation
Overnight fasting is preferred. Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw.
Minimum Volume
1.3 mL
Instructions
Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate hemolysis • Gross hemolysis • Grossly lipemic • Gross icterus • Serum Separator Tube (SST®) • Specimen other than serum • Heavy visible particulate matter
Methodology
Cell Culture (CC) • Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Clinical Significance
Patients with a chronic form of urticaria who are positive with the functional Histamine Release (Chronic Urticaria) test have an autoimmune basis for their disease. A positive result does not indicate which autoantibody (anti-IgE or anti-Fc epsilon RI alpha chain) is present. A positive anti-IgE antibody does not exclude the presence of anti-Fc epsilon RI alpha chain antibody.
