Platelet Antibody, Direct (IgG)

Test Code

91740

CPT Codes
86023

Preferred Specimen

10 mL whole blood collected in an ACD solution A (yellow-top) tube

Minimum Volume

5 mL

Other Acceptable Specimens

Whole blood collected in: ACD solution B (yellow-top) tube

Instructions

Collect 10 mL of whole blood in ACD (yellow-top) tube. Transport at room temperature immediately after collection.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemia • Clotted specimens • Received refrigerated • Received frozen • Icteric

Methodology
Flow Cytometry (FC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report Available: 3-4 days

Clinical Significance

Platelet associated IgG, IgA, and IgM (PAIgG, PAIgM, PAIgA) detection is useful in identifying immune-mediated platelet destruction. Elevated PAIgG is associated with autoimmune thrombocytopenia purpura (ITP) as well as thrombocytopenia in systemic lupus erythromatous (SLE), carcinoma, HIV, lymphoma, Hodgkin's disease and Hashimoto's thyroiditis.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.