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Human Anti-mouse Antibody (HAMA)
Test Code1468
CPT Codes
83520
Preferred Specimen
1 mL frozen serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen -20° C: 21 days
Frozen -70° C: 90 days
Refrigerated: 24 hours
Frozen -20° C: 21 days
Frozen -70° C: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross lipemia • Serum Separator Tube (SST®)
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
A.M. Sets up 1 day a week.
Report Available
Reports in 6 days.
Clinical Significance
The presence of Human Anti-mouse Antibody (HAMA) has been associated with patients receiving injections of Murine Monoclonal Antibody (MAB) for diagnostics and/or therapeutic purposes. HAMA produced in response to monoclonal antibody therapy may interfere with therapeutic efficacy. Therefore, it is recommended that baseline HAMA levels are determined prior to the initiation of therapy with murine-derived proteins.
