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Cyclin D1 (BCL 1), IHC with Interpretation (15474X)

Test Code
89011N


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin embedded tissue block in IHC specimen transport kit


Other Acceptable Specimens
4-micron unstained slides (x5) or fixed tissue or tissue in neutral buffered formalin


Instructions
Do not freeze. Pathology report is required.


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Methodology
Immunohistochemical Assay (IHC)

Setup Schedule
A.M. Sets up 6 days a week.


Clinical Significance
Approximately 65% of mantle cell lymphomas (MCL) are characterized by a t (11; 14) (q13; Q32) gene translocation that causes deregulation of the expression of the BCL-1 gene. This abnormality in turn leads to deregulation of Cyclin D1. Detection of Cyclin D1 is useful in detecting disease.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.