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ZAP-70
Test Code16000
CPT Codes
88184, 88185
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Other Acceptable Specimens
Sodium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • ACD Solution B (yellow-top) tube
Methodology
Flow Cytometry (FC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 4 days
Clinical Significance
Patients with chronic lymphocytic leukemia have variable outcome. Some live with their disease for more than 25 years and some die within a few years. ZAP70 can predict patients who have aggressive disease and need aggressive therapy.