ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic)

Test Code

10642

CPT Codes
81401 <br /> **Testing will not be run on minors**

Physician Attestation of Informed Consent

This genetic test requires provider confirmation that patient informed consent has been received if the ordering provider is located in AK, AZ, DE, FL, GA, IA, MA, MN, MT, NV, NH, NJ, NY, OR, SC, SD, or VT or testing is performed in MA.

Preferred Specimen

8 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

6 mL whole blood • 3 mL saliva

Other Acceptable Specimens

4 mL saliva collected in an OGD-500 Oragene-Dx or OGD-600 Oragene Dx collection kit

Instructions

Athena does not perform ApoE testing for individuals under the age of 18. Pre-test and post-test genetic counseling is strongly recommended.

Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old. Immediate shipping is recommended to optimize DNA quality and quantity.

Transport Temperature

Room temperature

Specimen Stability

Whole blood
Room temperature: 10 days
Refrigerated: 10 days
Frozen: 90 days

Saliva
⁠⁠⁠⁠⁠⁠⁠Room temperature: 1 year
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Samples from patients less than 18 years old

Methodology
Restriction Fragment Length Polymorphism (RFLP)

FDA Status
⁠⁠⁠⁠⁠⁠⁠This test was developed and its performance characteristics have been determined by Athena Diagnostics. Performance characteristics refer to the analytical performance of the test.

Setup Schedule

Report available: 7-14 days

Clinical Significance

Detection of APOE2, E3, E4 alleles.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.