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Advanced Lipid Panel, Cardio IQ®
Test Code92145
CPT Codes
82465, 83718, 84478, 83704, 82172, 83695
Includes
Cardio IQ® Cholesterol, Total
Cardio IQ® HDL Cholesterol
Cardio IQ® Triglycerides
Cardio IQ® Non-HDL and Calculated Components
Cardio IQ® Lipoprotein Fractionation, Ion Mobility
Cardio IQ® Apolipoprotein B
Cardio IQ® Lipoprotein (a)
If Triglyceride is >400 mg/dL, then Cardio IQ® Direct LDL will be performed at an additional charge.
If Triglyceride is extremely elevated, > 1293 mg/dL, this causes interference in the Cardio IQ® Direct LDL assay, therefore this test cannot be added.
Preferred Specimen
3 mL serum AND 1 mL serum
Patient Preparation
Fasting is not required prior to collection of a lipid panel.
The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been. . . determined to interfere with assays for. . . cholesterol, uric acid" where "NAC interference may lead to falsely low results." According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hour, a second dose of 50 mg/kg administered over 4 hrs and a third dose of 100 mg/kg administered over 16 hrs.
Minimum Volume
1.75 mL AND 0.25 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Moderate to grossly icteric • Grossly lipemic
Methodology
Enzymatic • Fixed Rate Nephelometry • Immunoturbidometric • Ion Mobility • Spectrophotometry (SP) • Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night Sets up 5 days a week.
Clinical Significance
The advanced lipid profile provides a more comprehensive assessment of dyslipidemia and cardiovascular risk than standard lipid panel measurements. Standard lipid panels measure total cholesterol, HDL-C, and triglycerides, and a calculated LDL-C, but do not capture all of the complexity of dyslipidemia and associated CVD risk. For a substantial number of individuals, lipoprotein measures such as LDL particle number, ApoB and Lp(a) add to the predictive power of standard lipid assessment of CVD risk. The advanced lipid profile combines a standard lipid panel with 3 additional tests: lipoprotein subfraction assessment by ion mobility of LDL particle number and LDL and HDL particle subclass concentrations, the ApoB test, and the Lp(a) test.