Epstein-Barr Virus Antibody Panel Comprehensive

Test Code

91838

CPT Codes
86663, 86665 (x2), 86664

Includes

Epstein-Barr Virus Early Antigen D Antibody (IgG)
Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgM)
Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)
Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgG)

Preferred Specimen

1 mL serum

Minimum Volume

0.8 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Methodology
Immunoassay (IA)

Setup Schedule

A.M. Sets up 5 days a week.

Clinical Significance

Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA-IgG is typically detectable at clinical presentation and persists for life. IgG recognizing Early Antigen D appears within a month after clinical presentation and typically lasts only 3-4 months; persistently elevated levels suggest reactivation or persistence of EBV infection. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.