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Pediatric Autoimmune Encephalitis Evaluation with Reflexes, CSF
Test Code18420
CPT Codes
84182 86052 86255 86341 86362
Includes
Aquaporin-4 (AQP4) Antibody, CBA with Reflex to Titer, CSF
Collapsin Response-Mediator Protein-5 (CRMP5/CV2) Antibody, Line Blot, CSF
Glutamic Acid Decarboxylase (GAD65) Antibody, Line Blot, CSF
MOG Antibody, CBA with Reflex to Titer, CSF
NMDAR1 Antibody, CBA with Reflex to Titer, CSF
If Aquaporin-4 (AQP4) Antibody, CBA is Positive, then Aquaporin-4 (AQP4) Antibody, Titer will be performed at an additional charge (CPT Code(s): 86052).
If MOG Antibody, CBA is Positive, then MOG Antibody, Titer will be performed at an additional charge (CPT Code(s): 86362).
If NMDAR1 Antibody, CBA is Positive, then NMDAR1 Antibody, Titer will be performed at an additional charge (CPT Code(s): 86256).
Collapsin Response-Mediator Protein-5 (CRMP5/CV2) Antibody, Line Blot, CSF
Glutamic Acid Decarboxylase (GAD65) Antibody, Line Blot, CSF
MOG Antibody, CBA with Reflex to Titer, CSF
NMDAR1 Antibody, CBA with Reflex to Titer, CSF
If Aquaporin-4 (AQP4) Antibody, CBA is Positive, then Aquaporin-4 (AQP4) Antibody, Titer will be performed at an additional charge (CPT Code(s): 86052).
If MOG Antibody, CBA is Positive, then MOG Antibody, Titer will be performed at an additional charge (CPT Code(s): 86362).
If NMDAR1 Antibody, CBA is Positive, then NMDAR1 Antibody, Titer will be performed at an additional charge (CPT Code(s): 86256).
Preferred Specimen
2.0 mL CSF
Minimum Volume
1.2 mL CSF
Transport Container
CSF: Plastic screw-cap vial
Transport Temperature
CSF: Room temperature preferred; Refrigerated acceptable;
_Frozen acceptable
_Frozen acceptable
Specimen Stability
CSF
__Room temperature: 7 Days
__Refrigerated: 14 Days
__Frozen: 21 Days
__Room temperature: 7 Days
__Refrigerated: 14 Days
__Frozen: 21 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Visible particulate matter
Methodology
Cell-based Immunofluorescence Assay • Line Blot
Setup Schedule
A.M. Sets up 3 days a week.
Report Available
Reports in 4 to 6 days.
Clinical Significance
Causes of autoimmune encephalitis differ between adults and children, largely due to the fact that autoimmune encephalitis in adults is more likely to be due to cancer, but in children more likely to have been caused by a viral infection. This panel will assess the most common causes of autoimmune encephalitis/encephalomyelitis in the pediatric age group.
