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FISH, Lymphoid Disorder, 6q Deletion
Test Code16593
CPT Codes
88271 (x2), 88275
Includes
If results are not possible, the test order may be canceled and replaced by code %39650 - Cytogenetics Communication
Preferred Specimen
3 mL bone marrow or 5 mL whole blood submitted in a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • 5x5 mm lymph node submitted in culture transport medium
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ Hybridization (FISH)
Setup Schedule
Set up: Daily; Report available: 5 days
Clinical Significance
Chromosome 6q deletion is a frequent abnormality in lymphoid malignancies including acute lymphoblastic leukemia (ALL), chronic lymphoid disorders (CLL) and small lymphocytic lymphoma (SLL), non-Hodgkin lymphoma, and multiple myeloma. It may be the sole clonal abnormality in as many as 30% of cases. Deletions may be small and difficult to resolve using conventional chromosome analysis. Deletion of the region 6q21 to 6q23 (SEC63/MYB) may be associated with loss of recessive tumor suppressor gene and may be an initial step in leukemogenesis. In CLL/SLL, patients with 6q deletions often have higher white blood cell counts and more extensive lymphadenopathy. Deletions in the 6q21-q23 region occur in approximately 7% of CLL/SLL patients.
