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Cortisol, LC/MS, Saliva, Sample 1
Test Code16675
CPT Codes
Restricted Client Code
Preferred Specimen
0.5 mL saliva collected in Salivette® Cortisol with blue screw-cap
Minimum Volume
0.2 mL
Other Acceptable Specimens
Saliva collected in: Super SAL™ Universal Saliva Kit, or Super SAL2™ Universal Saliva Kit
Instructions
a. Saliva collection should be done at the earliest 60 min after brushing teeth, a meal (liquid/solid food intake) or oral intake of medication and 10 min after rinsing the mouth with water in order to avoid contamination of the saliva by interfering substances.
b. Remove the swab from the Salivette.
c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 min without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.
d. Return the swab with the absorbed saliva to the Salivette.
e. Replace the stopper.
f. Refrigerate the Salivette immediately.
b. Remove the swab from the Salivette.
c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 min without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.
d. Return the swab with the absorbed saliva to the Salivette.
e. Replace the stopper.
f. Refrigerate the Salivette immediately.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 6 months
Refrigerated: 21 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • White-top Salivette® collection devices
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night Sets up 5 days a week.
Report Available
Reports in 2 to 6 days.
Clinical Significance
Measurements of salivary cortisol can be useful in the screening of patients for Cushing's syndrome and other adrenal disorders. Specific reference ranges have been defined based upon the time of day that specimen is collected. These reference intervals have been defined using specimens obtained from individuals adhering to a normal sleep/wake cycle.
