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Cortisol, LC/MS, Saliva, Sample 4
Test Code16709
CPT Codes
82533<br><strong>Restricted Client Code</strong>
Preferred Specimen
0.5 mL saliva collected in a Salivette® Cortisol with blue screw-cap
Minimum Volume
0.2 mL
Other Acceptable Specimens
Super SAL™ or Super SAL2™ Universal Saliva Kit
Instructions
a. Saliva collection should be done at the earliest 60 minutes after brushing teeth, a meal (liquid/solid food intake) or oral intake of medication and 10 minutes after rinsing the mouth with water in order to avoid contamination of the saliva by interfering substances.
b. Remove the swab from the Salivette.
c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 minutes without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.
d. Return the swab with the absorbed saliva to the Salivette.
e. Replace the stopper.
f. Refrigerate the Salivette immediately.
b. Remove the swab from the Salivette.
c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 minutes without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.
d. Return the swab with the absorbed saliva to the Salivette.
e. Replace the stopper.
f. Refrigerate the Salivette immediately.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 6 months
Refrigerated: 21 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • White-top Salivette collection devices
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Night Sets up 5 days a week.
Report Available
Reports in 2 to 6 days.
Clinical Significance
Measurements of salivary cortisol can be useful in the
screening of patients for Cushing's syndrome and other
adrenal disorders. Specific reference ranges have been
defined based upon the time of day that specimen is
collected. These reference intervals have been defined
using specimens obtained from individuals adhering to a
normal sleep/wake cycle.
screening of patients for Cushing's syndrome and other
adrenal disorders. Specific reference ranges have been
defined based upon the time of day that specimen is
collected. These reference intervals have been defined
using specimens obtained from individuals adhering to a
normal sleep/wake cycle.
