Prostate Triple Stain (P504S, HMW Keratins, P63), IHC with Interpretation

Test Code

91478

CPT Codes
88344

Preferred Specimen

Formalin fixed paraffin embedded tissue in IHC specimen transport kit

Other Acceptable Specimens

5 unstained, positively charged slides submitted in IHC specimen transport kit

Instructions

Please include Surgical Pathology Report

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Methodology
Immunohistochemistry (IHC)

Setup Schedule

A.M.

Report Available

Reports in 2 to 3 days.

Clinical Significance

Pathologic evaluation of prostate cancer can be challenging, especially when there is a small focus of cancer. Because benign prostate glands contain basal cells, while cancerous glands do not, differential staining of basal cells in the prostate may be useful for diagnosis. This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial tissue. This combination may help differentiate prostate cancer from precancerous lesions such as prostatic intraepithelial neoplasia (PIN), especially when tissue is limited.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.