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Prostate Triple Stain (P504S, HMW Keratins, P63), IHC with Interpretation
Test Code91478
CPT Codes
88344
Preferred Specimen
Formalin fixed paraffin embedded tissue in IHC specimen transport kit
Other Acceptable Specimens
5 unstained, positively charged slides submitted in IHC specimen transport kit
Instructions
Please include Surgical Pathology Report
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
A.M.
Report Available
Reports in 2 to 3 days.
Clinical Significance
Pathologic evaluation of prostate cancer can be challenging, especially when there is a small focus of cancer. Because benign prostate glands contain basal cells, while cancerous glands do not, differential staining of basal cells in the prostate may be useful for diagnosis. This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial tissue. This combination may help differentiate prostate cancer from precancerous lesions such as prostatic intraepithelial neoplasia (PIN), especially when tissue is limited.