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Lynch Syndrome Tumor Panel, IHC without Interpretation
Test Code91333
CPT Codes
88342 (x4)
Includes
MLH1, MSH2, MSH6, PMS2
Preferred Specimen
1 formalin fixed paraffin embedded tissue block cubmitted in an IHC specimen transport kit
Other Acceptable Specimens
10 unstained, positively charged slides, submitted in an IHC specimen transport kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
A.M. Sets up 5 days a week.
Clinical Significance
Genetic defects in these four mismatch repair proteins underlie most cases of Lynch syndrome or hereditary non-polyposis colorectal carcinoma (HNPCC). This IHC panel looks for loss of expression of one or more of these proteins in cases of suspected HNPCC in tumor tissues from colorectal carcinomas, endometrial carcinomas, sebaceous adenoma/carcinoma or other adnexal tumors. If IHC results are abnormal, guidance is provided in the report on the recommended next step in the workup.