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Lysozyme (Muramidase)
Test Code619
CPT Codes
85549
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 15 days
Frozen: 18 days
Refrigerated: 15 days
Frozen: 18 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic
Methodology
Enzymatic
Setup Schedule
P.M. Sets up 2 days a week.
Report Available
Reports in 1 day.
Clinical Significance
Lysozyme in the serum is primarily due to the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign and malignant processes. Serum lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and levels decrease with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.
