FISH, Multiple Myeloma, 1q21

Test Code

91388

CPT Codes
88271 (x2), 88275

Preferred Specimen

3 mL bone marrow submitted in culture transport medium

Minimum Volume

1 mL

Other Acceptable Specimens

Bone marrow collected in: Sodium heparin (green-top) tube, sodium heparin (royal blue-top) tube, or sodium heparin (tan-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Methodology
Fluorescence in situ hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 5-7 days

Clinical Significance

Chromosomal abnormalities are detected in 80-85% of myeloma patients. One or more extra copies of 1q21 has been associated with poor prognosis in patients with newly diagnosed myeloma, whether as a sole abnormality or in combination with other nonrandom abnormalities. Prognostic factors such as this are helpful to clinicians in determining therapy and predicting long-term survival.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.