Rheumatoid Arthritis Diagnostic Panel 2

Test Code

91472

CPT Codes
86431, 86200, 83520

Includes

Rheumatoid Factor
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Mutated Citrullinated Vimentin (MCV) Antibody

Preferred Specimen

3 mL serum

Minimum Volume

1.5 mL

Instructions

See individual assays

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

See individual tests

Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Immunoturbidimetric Assay

Setup Schedule

See individual assays

Clinical Significance

Autoantibody testing has a major role in the diagnosis of RA. This panel includes Rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) and anti-mutated citrullinated vimentin (MCV). RF is found in a majority of patients with RA but is not specific for the diagnosis. Anti-CCP antibody is more sensitive and highly specific. RF and anti-CCP are included in the most recent classification criteria for RA. The past several years have seen a search for biomarkers which might increase sensitivity in order to identify the minority of RA patients who are negative for either RF or CCP, especially early in the course of disease. The addition of anti-MCV increases sensitivity for RA when tested together with RF and CCP.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.