Lynch Syndrome Tumor Panel, IHC with Interpretation

Test Code

91332

CPT Codes
88342, 88341 (x3)

Includes

MLH1, MSH2, MSH6, PMS2

Preferred Specimen

1 formalin-fixed, paraffin-embedded tissue block in an IHC specimen transport kit

Other Acceptable Specimens

10 unstained, positively charged slides, submitted in an IHC specimen transport kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Methodology
Immunohistochemistry (IHC)

Setup Schedule

A.M.

Report Available

Reports in 2 to 3 days.

Clinical Significance

Genetic defects in these four mismatch repair proteins underlie most cases of Lynch syndrome or hereditary non-polyposis colorectal carcinoma (HNPCC). This IHC panel looks for loss of expression of one or more of these proteins in cases of suspected HNPCC in tumor tissues from colorectal carcinomas, endometrial carcinomas, sebaceous adenoma/carcinoma or other adnexal tumors. If IHC results are abnormal, guidance is provided in the report on the recommended next step in the workup.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.