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Drug Toxicology Phentermine, with Confirmation, Oral Fluid
Test Code13647
CPT Codes
80307
Includes
If screening drug class result is equal to or greater than the cutoff, then confirmation testing will be performed at an additional charge (CPT code(s): 80324; HCPCS: G0480).
Preferred Specimen
1 mL oral fluid inserted into 3 mL buffer tube collected in Quantisal™ device
Patient Preparation
Quantisal™: Avoid any food or drink consumption, or gum or tobacco use for 10 minutes prior to collecting. If donor's mouth is not empty immediately prior to collection, have subject rinse mouth with water (up to 4 oz) and wait a minimum of 10 minutes before collecting a specimen.
Minimum Volume
See preferred specimen collection guidance for minimum
Instructions
Quantisal™: Using the standard Quantisal™ collection container, place the swab under the tongue. Donor should keep head down to allow gravity to help with saliva collection. Leave in place until blue dye indicates that the collection pad is saturated sufficiently. Follow collection instructions on package. Quantisal™ collection device (1 mL oral fluid inserted into 3 mL buffer tube).
Transport Temperature
Quantisal™: Room temperature
Specimen Stability
Quantisal™
Room temperature: 10 days
Refrigerated: 30 days
Frozen: 30 days
Room temperature: 10 days
Refrigerated: 30 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens submitted in a non-Quantisal™ collection device • Specimens received with any food debris or foreign objects present in the sample • Multiple swabs present in a single device • No swab present with the device • Quantisal™: Collection wand inverted inside the collection tube
Methodology
Mass Spectrometry (MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 3-5 days
Clinical Significance
Phentermine is a prescription stimulant. Because taking phentermine comes with a risk of dependence, it is considered a controlled substance. It's chemically similar to the stimulant amphetamine, which is also a controlled substance. The test is a definitive assay using Liquid Chromatography Mass Spectroscopy methodology. Therapeutic urine drug monitoring of phentermine is important for ensuring compliance to treatment strategies, as well as ensuring non-diversion for illicit purposes. Urine or oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs. Use of serum/plasma should be limited to anuretic patients, or where a patient's clinical appearance does not coincide with their prescribed medications. No single monitoring approach provides adequate information about the pattern or dose of patient drug use. Safest prescribing habits should include a combination of tools and laboratory test results to correctly detect drug use patterns. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.
